Basal forebrain cholinergic projections to the frontal cortex in mice: A combined acetylcholinesterase histochemistry and retrograde tracer study
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چکیده
The topographical organization of the basal forebrain cholinergic projections to the frontal cortex in mice was assessed through acetylcholinesterase histochemistry and retrograde colloidal gold-wheat germ agglutinin-horseradish peroxidase double labeling. The anterior part of the magnocellular basal nucleus, and the horizontal limb of the diagonal band of Broca project to the mediodorsal anterior frontal cortex, while the posterior parts of the magnocellular basal nucleus project to the mediodorsal posterior and lateral regions of the frontal cortex. The intermediate regions of the magnocellular basal nucleus project diffusely upon all dorsal regions of the frontal cortex.
منابع مشابه
Neurons in the basal forebrain project to the cortex in a complex topographic organization that reflects corticocortical connectivity patterns: an experimental study based on retrograde tracing and 3D reconstruction.
The most prominent feature of the Basal Forebrain (BF) is the collection of large cortically projecting neurons (basal nucleus of Meynert) that serve as the primary source of cholinergic input to the entire cortical mantle. Despite its broad involvement in cortical activation, attention, and memory, the functional details of the BF are not well understood due to the anatomical complexity of the...
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